The Hidden Side Effect of Ozempic: Why Rapid Weight Loss Is Aging Smiles

You’ve probably seen the viral Ozempic (semaglutide) before-and-after photos online. Pounds melt away fast, leaving dramatic transformations. But while bodies change, something else is happening—something few people talk about: your face. Doctors are calling it “Ozempic mouth,” and it’s aging smiles faster than expected.

What Doctors Are Seeing

In her New York clinic, Dr. Michele Green notices it daily. Patients lose facial volume, which causes wrinkles, sagging, and droopy areas around the mouth. Deep lines carve corners, lips wrinkle, and skin gathers under the chin. Bright, youthful smiles suddenly appear older—sometimes decades older.

Plastic surgeon Dr. Barry Weintraub explains the reason: rapid fat loss strips the skin’s underlying support. Without this cushion, skin collapses, creating loose, fragile, and wrinkled areas. These “lipstick lines” turn formerly full faces into hollow, aged ones.

Celebrities Show the Signs

Even famous faces aren’t immune. Sharon Osbourne, Rebel Wilson, and Whoopi Goldberg have shared their weight-loss journeys publicly and show noticeable facial volume loss. Men also face this effect. Actor Harvey Fierstein lost 120 pounds on a similar medication, Zepbound, only to see droopy, loose skin transform his face dramatically.

It’s More Than Just the Mouth

“Ozempic mouth” is part of a bigger issue called “Ozempic face.” Rapid weight loss creates sunken cheeks, hollow eyes, and gaunt appearances. Users report aged-looking feet, bottom deflation, and other body changes. This medication reshapes the body—not just the weight.

Millions Could Be Affected

About one in eight Americans has tried these injections, often for weight loss rather than diabetes. Many users go unreported due to stigma or compounded prescriptions. With millions using these treatments, cosmetic issues are increasingly visible—especially online and among celebrities.

Fixing the Damage

Many patients turn to dermal fillers. These gel-like injections replace lost facial fat, smooth wrinkles, and restore fullness. However, each syringe costs $700–$2,000, and multiple syringes are often needed for noticeable results.

Advanced options like Thermage use radio waves to stimulate collagen and tighten skin. Results appear in four to six months and can last about 18 months. Still, treatments cost $1,500–$3,500 per session, making them pricey for most people.

Preventing Ozempic Mouth

Doctors recommend slowing weight loss to protect skin. Gradual reductions allow the skin to adjust naturally. Dr. Ramer Bass suggests small, protein- and fiber-rich meals to maintain skin hydration and elasticity. Seeing a dermatologist early can prevent damage rather than fix it later.

Cosmetic Industry Responds

Dermal filler use has nearly tripled in the last decade, rising from 1.8 million treatments in 2010 to 5.3 million in 2023. Clinics now tailor services for patients with prescription-related facial changes. The booming beauty industry is helping—but at a cost.

The Real Price of Rapid Weight Loss

Cosmetic fixes aren’t cheap. Users may spend thousands yearly, with repeated sessions required for maintenance. Many combine treatments to restore full facial volume. Anyone considering weight-loss injections should budget for these long-term cosmetic expenses. Rapid transformation often comes with a hidden financial and physical price.