South Park stirred up a lot of reaction with an episode that had Kristi Noem in an outlandish storyline. It mixed politics with ridiculous scenes and she was not impressed. She talked about it after seeing it.
In the show, Noem is the Secretary of Homeland Security and she is shown killing puppies while a makeup crew works on her face. This plays on her own autobiography where she wrote about shooting a dog, and also on talk about her MAGA makeover.

The episode pushes it further by showing her kill Krypto, Superman’s dog, and then walking into a pet store with a rifle while gunshots are heard.
She told the news: “It’s so lazy, it constantly makes fun of women for how they look. Only the liberals and the extremists do that. If they wanted to criticize my job, go ahead and do that, but clearly they can’t. They just pick something petty like that.” She said the focus was on her looks rather than her work.
The same episode took jabs at Charlie Kirk and also had a strange plot with Dora the Explorer. In that part, school counselor Mr. Mackey loses his job and ends up joining ICE. His first task is a raid on the Dora set, which leads to him going to Mar a Lago as a reward.

Instead of a normal trip, Mackey is offered a meeting with Satan and Donald Trump, with lines hinting at Jeffrey Epstein. Dora is shown as a masseuse at the resort before she escapes. The South Park creators have not commented, and based on their past they probably will not.